FAQs
Frequently asked questions about gMG and targeted treatment
What is generalized myasthenia gravis (gMG)?
gMG is a rare, chronic autoimmune disorder where the body’s immune system attacks the communication between nerves and muscles, causing muscle weakness and fatigue. It can affect muscles throughout the body, making everyday tasks like climbing stairs or brushing teeth difficult.
What are the symptoms of gMG?
Symptoms can vary from person to person. gMG can affect your nerves and muscles, causing muscle weakness and fatigue that can feel overwhelming. These symptoms can be debilitating and can make activities of daily living like talking, chewing, swallowing, breathing, brushing teeth or hair, and arising from a chair very challenging.
What is targeted therapy for gMG?
Targeted therapies for gMG focus on specific parts of the immune system causing the disease. These treatments include FcRn blockers, which help reduce harmful antibodies, and C5 inhibitors, which target a protein in the immune system that contributes to muscle damage.
How does an FcRn blocker work?
FcRn blockers target the neonatal Fc receptor (FcRn), a protein that helps harmful antibodies stay in the body longer. By blocking this protein, these therapies may help reduce the number of antibodies attacking the neuromuscular junction, improving muscle strength.
How does a C5 inhibitor work?
C5 inhibitors are treatments that block a protein called C5, which is part of the immune system’s complement pathway. By inhibiting C5, these therapies may help prevent the immune system from damaging muscle cells in gMG.
How are these targeted treatments given?
FcRn blockers and C5 inhibitors can be administered in different ways. Some treatments are given through regular injections, while others are administered through infusions by a healthcare provider.
How do I know if targeted therapy is right for me?
If you're an adult with gMG who has symptoms that are not well-controlled or who is not satisfied with your current treatment plan, it may be time to talk to your doctor about targeted treatment. Your doctor can help you understand the options based on your unique symptoms and health history.
How can I learn more about treatment options?
For more information about treatment options such as targeted treatments for gMG, you can talk to your healthcare provider, visit trusted educational websites, or sign up for resources to stay informed on the latest options from UCB.
